Journal article
Population-based estimate of the contribution of TP53 mutations to subgroups of early-onset breast cancer: Australian breast cancer family study
J Mouchawar, C Korch, T Byers, TM Pitts, E Li, MRE McCredie, GG Giles, JL Hopper, MC Southey
Cancer Research | Published : 2010
Abstract
Although germline TP53 mutations have been identified in women with breast cancer from families meeting Li-Fraumeni criteria, their contribution to breast cancer per se is not well known, but is thought to be minimal. We aimed to determine the prevalence of germline TP53 mutations in subgroups of early-onset breast cancer. Germline TP53 mutation status was assessed by DNA sequencing, screening for heterozygous single-nucleotide polymorphisms, and Multiplex Ligation-Dependent Probe Amplification analyses. From an Australian population-based series of invasive breast cancers, we studied (a) 52 women diagnosed before age 30 years unselected for family history [very early-onset (VEO)] and (b) 42..
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Awarded by National Cancer Institute
Funding Acknowledgements
Clinical research training grant CRTG-00-198-01-CCE from the American Cancer Society (J. Mouchawar). Core support grant to the University of Colorado Cancer Center from the National Cancer Institute of the NIH (P30 CA046934). The ABCFS was funded by the National Health and Medical Research Council (NHMRC), the Victorian Health Promotion Foundation, the New South Wales Cancer Council, the Peter MacCallum Cancer Institute, the Inkster-Ross Memorial Fund, and, in part, by the NIH, as part of the Cancer Family Registry for Breast Cancer Study (CA 69638). This work used data collected from the Breast Cancer Family Registries Studies (Breast CFRs), funded by the National Cancer Institute under RFA # CA-95-003 and through cooperative agreements with the Fox Chase Cancer Center, Huntsman Cancer Institute, Columbia University, Northern California Cancer Center, Cancer Care Ontario, and University of Melbourne. The content of this article does not necessarily reflect the views or policies of the National Cancer Institute or any of the collaborating centers in the CFRs, nor does mention of trade names, commercial products, or organizations imply endorsement by the U. S. Government or the CFRs Centers. J. Hopper is an NHMRC Australian Fellow and M. Southey is a Senior Research Fellow of the NHMRC.